D-Kynurenine 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。

D-Kynurenine is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.

D-Kynurenine (10-100 μM) induces DER-enhancement and positively regulates the transfer of 95D cells, which is attenuated after siRNAAhr treatment in VIM and E-cadherin. D-Kynurenine (10 and 40 μM) significantly increases VIM expression and induces CYP1A1 upregulation. D-Kynurenine (10 μM) significantly attenuates the level of E-cadherin[4].

13441-51-5

C10H12N2O3

208.21

ZINC901103;D-尿嘧啶;(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

H2O:5 mg/mL (24.01 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years