INOSine 是由腺苷分解代谢产生的一种内源性嘌呤核苷，是腺苷受体A1R和A2AR的激动剂，具有抗炎免疫调节，抗伤害和神经保护作用。

Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.

Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2]

The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2]

58-63-9

C10H12N4O5

268.23

肌苷;INO 495;NSC 20262

H2O:43 mg/mL (160.3 mM)
Ethanol:<1 mgml
DMSO:49 mg/mL (182.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years