JH-X-119-01 是白介素 1 受体相关激酶 1 的选择性抑制剂。它能够改善 LPS 诱导的小鼠败血症。它可以抑制 IRAK1(IC50:9 nM),在浓度达到 10 μM 时,也不会对 IRAK4 产生抑制作用。
产品描述
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.
体外活性
JH-X-119-01 exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88.?Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems.
Cas No.
2227368-54-7
分子式
C25H20N6O3
分子量
452.474
储存和溶解度
DMSO:12 mg/ml (26.52 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years