您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > Medetomidine
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Medetomidine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Medetomidine图片
CAS NO:86347-14-0
包装与价格：
包装价格(元)
50mg电议
10mg电议

产品介绍
Medetomidine(Domtor) 是一种有效的、高选择性的 α2-adrenoceptor 激动剂（α2-和 α1-adrenoceptors 的 Ki 值分别为 1.08 和 1750 nM）。
Cas No.86347-14-0
别名美托咪定
化学名5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole
Canonical SMILESCC1=C(C)C(C(C2=CN=CN2)C)=CC=C1
分子式C13H16N2
分子量200.28
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

References:
[1]. Wenger S, Hoby S, Wyss F, Adami C, Wenker C.Anaesthesia with medetomidine, midazolam and ketamine in six gorillas after premedication with oral zuclopenthixol dihydrochloride.Vet Anaesth Analg. 2012 Aug 8. doi: 10.1111/j.1467-2995.2012.00761.x.
[2]. Gerritsmann H, Stalder GL, Seilern-Moy K, Knauer F, Walzer C.Comparison of S(+)-ketamine and ketamine, with medetomidine, for field anaesthesia in the European brown hare (Lepus europaeus).Vet Anaesth Analg. 2012 Jul 13. doi: 10.1111/j.1467-2995.2012.00754.x.
[3]. Kallio A, Koulu M, Scheinin H, Viikari J, Scheinin M.Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man.Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5.
[4]. Virtanen R, Savola JM, Saano V, Nyman L.Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist.Eur J Pharmacol. 1988 May 20;150(1-2):9-14.
[5]. Stenberg D, Salvén P, Miettinen MV.Sedative action of the alpha 2-agonist medetomidine in cats.J Vet Pharmacol Ther. 1987 Dec;10(4):319-23.