Netarsudil hydrochloride 是 Rho 相关蛋白激酶 (ROCK) 和去甲肾上腺素转运蛋白 (NET) 的抑制剂,可有效降低眼压 (IOP)。
产品描述
Netarsudil Dihydrochloride is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction.
体内活性
Netarsudil Dihydrochloride (AR-13324 Dihydrochloride; 0.04%, 50 ΜL)reduces intraocular pressure (IOP) in normotensive monkey eyes [1]. Netarsudil Dihydrochloride (0.04%) produces a statistically significant lowering of episcleral venous pressure (EVP) in Dutch Belted rabbits [2].
Cas No.
1253952-02-1
分子式
C28H29Cl2N3O3
分子量
526.45
别名
AR-13324 Dihydrochloride
储存和溶解度
DMSO:5 mg/mL (9.50 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years