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SAR407899
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SAR407899图片
CAS NO:923359-38-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
SAR407899 是一种选择性的 ATP 竞争性ROCK抑制剂,对ROCK-2的IC50值为 135 nM,对人和大鼠ROCK-2的Ki值分别为 36 和 41 nM。它是 Rho 激酶抑制剂,有效抑制 endothelin-1 诱导的肾阻力动脉收缩。

产品描述

SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.

体内活性

In vivo, SAR407899 dose-dependently induced rabbit penile erection, with greater potency and longer duration of action than sildenafil[1].

动物实验

Compared the effects of SAR407899, the Rho-kinase inhibitor Y-27632 and the PDE5 inhibitor sildenafil for their ability to relax corpus cavernosum strips contracted with phenylephrine in healthy and diabetic animals. Strips were obtained from WKY, spontaneous hypertensive (SHR), control CD, and diabetic CD rats, humans, control and diabetic rabbits. Diabetes was induced by streptozotocin or alloxan injection. In vivo penile erection (length) induced by drugs was measured in conscious rabbits[1].

Cas No.

923359-38-0

分子式

C14H16N2O2

分子量

244.29

储存和溶解度

DMSO:6 mg/mL (24.56 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years