CAS NO: | 58020-43-2 |
包装: | 25mg |
市场价: | 2552元 |
Cas No. | 58020-43-2 |
别名 | 4-羟基妥洛特罗,4-Hydroxytulobuterol;HOKU 81;HOKU81 |
化学名 | 4-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol |
Canonical SMILES | CC(C)(C)NCC(C1=C(C=C(C=C1)O)Cl)O |
分子式 | C12H18ClNO2 |
分子量 | 243.73 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | HOKU-81, a new bronchodilator, is one of the metabolites of tulobuterol. IC50 Value: Target: Adrenergic ReceptorEffects of HOKU-81 on isolated trachea and atria of guinea pigs were compared with those of various bronchodilators. HOKU-81 appears to be a potent and selective beta 2-stimulant with a slight inotropic action. HOKU-81 was approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effect on the isolated tracheal smooth muscle preparation of guinea pigs. This effect of HOKU-81 seems to be due to direct action on the adrenergic beta-receptor. References: |