Foxy-5 acetate 是 Wnt 5A 的激动剂，Wnt 5A 是 Wnt 家族的非经典成员。 Foxy-5 acetate 损害上皮癌细胞的迁移和侵袭，触发细胞溶质游离钙信号传导，而不影响 β-连环蛋白活化。

Foxy-5 acetate is an agonist of Wnt 5A which is a non-canonical member of the Wnt family. Foxy-5 acetate impairs the migration and invasion of epithelial cancer cells triggers cytosolic free calcium signaling without affecting β-catenin activation.

In an orthotopic mouse model, Foxy-5 acetate effectively reduces the metastatic spread of Wnt 5A-low prostate cancer cells[2]. In a xenograft mouse model of human colonic cancer, Foxy-5 acetate reduces the number of colonic cancer stem cells[3].

TP1565L

C28H46N6O14S2

754.83

Foxy-5 acetate(881188-51-8 free base)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years