NRX-252262 是 β-CATenin 与同源 E3 ligaseSCFβ-TrCP 的相互作用增强剂，能够诱导 β-CATenin 的降解，其 EC50=3.8 nM。

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50：3.8 nM)

NRX-252262 also induces S33E/S37A mutant β-catenin degradation at an even lower concentration of ~35?μM

2438637-61-5

C23H17Cl2F3N2O4S

545.36

DMSO:8 mg/mL (14.67 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years