SB 4 是苯并恶唑骨形态发生蛋白 4 (BMP4) 信号激动剂(EC50:74 nM)，能够稳定细胞内 p-SMAD-1/5/9 ，激活 BMP 信号。它还能激活典型 BMP 信号通路中的 BMP4 靶基因 (DNA 结合抑制剂，Id1和Id3)。

SB 4 is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)

SB4, that rapidly stimulated BMP signaling in these cells. Activation of BMP signaling by sb4 increased the phosphorylation of key second messengers (SMAD-1/5/9) and also increased expression of direct target genes (inhibitors of DNA binding, Id1 and Id3) in canonical BMP signaling[1].

100874-08-6

C14H10BrNOS

320.2

SB 4

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years