SAG hydrochloride (912545-86-9(free base)) 是一种含有氯苯并噻吩的化合物，可作为 Smo 激动剂。

SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.

SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. [1] SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. [2] SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.

In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities.

Animal Models: RatFormulation: DMSODosages: 2.5 nMAdministration: Intracerebroventricular administration(Only for Reference)

T4211

C28H29Cl2N3OS

526.52

Smoothened Agonist HCl

Ethanol:38 mg/mL (72.2 mM)
DMSO:66 mg/mL (125.4 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years