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Orobol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Orobol图片
CAS NO:480-23-9
包装与价格:
包装价格(元)
1 mg电议
5 mg电议

产品名称
3’,4’,5,7-tetrahydroxy-isoflavon
3'-Hydroxygenistein
3',4',5,7-四羟基异黄酮
产品介绍
Orobol 是酪氨酸特异性蛋白激酶和磷脂酰肌醇转换的抑制剂。Orobol 抑制 PI3K,对 PI3K α/β/γ/K/δ 的 IC50 为 3.46-5.27 μM。 Orobol 具有抗皮肤老化和抗肥胖的作用。

产品描述

Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibits anti-skin-aging and anti-obesity effects.

体外活性

Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK with IC50s of 1.24-4.45 μM. Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone, and insulin (MDI))-induced phosphorylation of 4E-BP1. Orobol binds to CK1ε in an ATP-competitive manner[3].

体内活性

In C57BL/6J mice, Orobol (10 mg/kg; intragastrically) attenuates high-fat diet-induced weight gain (17.3%) and lipid accumulation without affecting food intake[3].

Cas No.

480-23-9

分子式

C15H10O6

分子量

286.24

别名

3’,4’,5,7-tetrahydroxy-isoflavon;3'-Hydroxygenistein;3',4',5,7-四羟基异黄酮

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years