Rotenone 是广泛分布于豆科蝶形科中的一种植物杀虫剂，是线粒体电子传递复合物 I 抑制剂。它通过促进线粒体活性氧的产生来诱导细胞凋亡。

Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae).

Mitogen Activated Protein Kinase (MAPK), Toll-like receptor, Wnt, and Ras signaling pathways are intensively involved in the effect of rotenone on the ENS[2]. Rotenone-induced cell death is reduced by MCE treatment as measured by a decline in the levels of pro-apoptotic proteins. In addition, MCE treatment significantly augments the levels of anti-apoptotic Bcl2 and blocks the release of cytochrome c, thereby alleviating the rotenone-induced dopaminergic neuronal loss, as evidenced by tyrosine hydroxylase (TH) immunostaining in the striatum[3].

Rotenone results in a significant increase in the excitatory amino acid neurotransmitters; glutamate and aspartate together with a significant decrease in the inhibitory amino acids, GABA, glycine and taurine are observed in the cerebellum of rat model of PD[1]. Rotenone (1.5, 2, or 2.5 mg/kg) causes a dose-dependent increase in α-synuclein in the substantia nigra. Furthermore, at 2 and 2.5 mg/kg, rotenone causes a significant decrease in the number of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra, and dopamine in the striatum in rats[4].

83-79-4

C23H22O6

394.423

Rotocide;Barbasco;Paraderil;Dactinol;Rotenon;鱼藤酮

DMSO:39.4 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years