Sodium Oxamate 是一种LDH抑制剂。 Sodium oxamate (SO) 通过下调 CDK1/cyclin B1 通路诱导 G2/M 细胞周期停滞，并通过增强线粒体 ROS 生成促进细胞凋亡。它抑制 L(+)-乳酸脱氢酶并破坏整个糖异生通路。

Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.It inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway.

NETosis and lactate accumulation during LPS induced sepsis in mice was inhibited by sodium oxamate, LDH inhibitor[1].

565-73-1

C2H2NNaO3

111.032

SO;oxamate sodium;Aminooxoacetic acid sodium salt;Oxamic acid sodium salt;草氨酸钠

DMSO:Insoluble
H2O:200 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years