Oenothein B 是一种聚（ADP-核糖）糖水解酶的特异性抑制剂。 Oenothein B 具有抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。

Oenothein B is a specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B shows antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties.

Oenothein B (15-45 μM; 24 hours) not only increased the level of intracellular reactive oxygen species (ROS) but also induced the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax). Oenothein B (15-45 μM; 12-72 hours) had a dose- and time-dependent inhibition rate effect on A549 cells exposure. Oenothein B (15-45 μM; 24 hours) effectively inhibited the proliferation of A549 cells by inducing apoptosis and arresting cells at the G1 stage[3].

In ICR mice, Oenothein B (100-300 mg/kg; p.o.) reduced neuroinflammation in the brain during systemic inflammation[2].

104987-36-2

C68H48O44

1569.08

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years