Azoramide是一种小分子调节剂,具有未折叠蛋白反应的抗糖尿病活性。
产品描述
Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
体外活性
Azoramide, a dual-function endoplasmic reticulum (ER) modulator, improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems.
体内活性
In two independent mouse models of obesity, Azoramide exhibits potent antidiabetic efficacy by improving insulin sensitivity and pancreatic β cell function.
Cas No.
932986-18-0
分子式
C15H17ClN2OS
分子量
308.82
储存和溶解度
DMSO:30.9 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years