Epiberberine 是一种从黄连中得到的生物碱，是AChE和BChE抑制剂，和非竞争性BACE1抑制剂。在 3T3-L1 细胞分化早期，它能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。它具有抗氧化作用，能够清除 ONOO-，可用于阿尔滋海默症和糖尿病的研究。

1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte differentiation. 3. Epiberberine, as the brightest FSA emitter among the alkaloids, can also serve as an efficient conformation probe for HTG DNA and discriminate the DNA G-quadruplex from the RNA counterpart.

6873-09-2

C20H18NO4

336.366

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:11 mg/mL(32.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years