ACTH (1-17) acetate 是一种有效的人黑皮质素 1 (MC1) 受体激动剂，具有高亲和力 (Ki = 0.21 nM)。

ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM).

ACTH (1-17) acetate induces a slight and not significant increase in growth hormone secretion even when micromolar concentrations of the peptide are employed in rat pituitary cultures[1]. ACTH (1-17) acetate showed an affinity for alpha-MSH with Ki of 0.13±0.005 nM[1].

When nocturnal animals became active, inhibition of DNA markers was noted when ACTH (1-17) acetate was administered 2 hours after the start of the daily dark span. When administered during this circadian phase, particularly larger doses were associated with a 24-hour lasting inhibition of DNA markers. When the same dose was injected 4 hours earlier, the inhibitory effect was much shorter [2].

TP1011L

C97H149N29O25S

2153.47

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years