MCL 0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂,IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症,在体内表现出抗焦虑样活性。
产品描述
Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and >10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
Cas No.
475498-26-1
分子式
C34H39N7O4
分子量
609.731
别名
MCL 0020
储存和溶解度
25% ethanol / water:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years