7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine with reduced activity compared with Agomelatine. Agomelatine (S20098; BAN, rINN; Valdoxan, Melitor, Thymanax) is a potent and specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. It is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). It shows low affinities to cloned human 5-HT2A and 5-HT1A. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C.

纯度：≥98%

CAS：166527-00-0