Men 10376 TFA(135306-85-3,free) 是一种有效的选择性速激肽 nk-2 受体拮抗剂，对大鼠小肠 nk-2 受体的 K I 值为 4.4 M。

Men 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.

Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].

Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].

TP1086

C59H69F3N12O12

1195.25

Men 10376 TFA;Neurokinin-2 receptor antagonist TFA

H2O:1.43 mg/mL (1.20 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years