Substance P 是一种神经肽，其内源性受体是神经激肽1受体，在中枢神经系统中作为神经递质和神经调节剂。

Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.

The desensitization and resensitization of neuropeptide substance P (SP) mediated by neurokinin 1 receptor (NK1-R), which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].

33507-63-0

C63H98N18O13S

1347.65

P物质;Neurokinin P

DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years