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Amitriptyline HCl(Elavil)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amitriptyline HCl(Elavil)图片
CAS NO:549-18-8
规格:≥98%
包装与价格:
包装价格(元)
10g电议
25g电议
50g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)313.86
FormulaC20H23N.HCl
CAS No.549-18-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 63 mg/mL (200.7 mM)
Water: 15 mg/mL (47.8 mM)
Ethanol: 63 mg/mL (200.7 mM)
Solubility (In vivo)

Chemical Name: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride

InChi Key: KFYRPLNVJVHZGT-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

SMILES Code: CN(C)CC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13.[H]Cl

Synonymstrade names: Elavil; Amitriptylin; Tryptanol; Damilen; Triptanol; Amitriptyline HCl; Amitriptyline hydrochloride;
实验参考方法
In Vitro

In vitro activity: Amitriptyline inhibits Forskolin-stimulated cyclic AMP accumulation with EC50 values of 16.2 μM in intact CHO/DOR cells. Amitriptyline causes a concentration-dependent stimulation of ERK1/2 and GSK-3β phosphorylation with EC50 values of 9.0 μM in CHO/DOR cells. Amitriptyline (15 μM) causes a stimulation of ERK1/2 phosphorylation in C6 cells. Amitriptyline (30 μM) inhibits Forskolin-stimulated adenylyl cyclase activity and antagonizes (–)-U50,488 inhibitory effect in rat nucleus accumbens. Amitriptyline binds the extracellular domain of both TrkA and TrkB and promotes TrkA-TrkB receptor heterodimerization. Amitriptyline (< 500 nM) promotes TrkA autophosphorylation in primary neurons and induces neurite outgrowth in PC12 cells. Amitriptyline selectively protects T17 cells from apoptosis with EC50 of 50 nM.

In VivoAmitriptyline (15 mg/kg, i.p.) activates TrkA and TrkB receptors and significantly reduces kainic acid-triggered neuronal cell death in mice. Amitriptyline (15 mg/kg and 30 mg/kg, i.p.) dose-dependently decreases the immobility time in the forced swimming test (FST) of mice. Amitriptyline (15 mg/kg, i.p.) shows a significant 24-h rhythm in the immobility time in the forced swimming test (FST) of mice. Amitriptyline (1 mg/kg and 3 mg/kg) significantly increases the total distance travelled of mice in novel cages. Amitriptyline (10 mg/kg p.o., twice daily) considerably attenuates the hypothermic response to 8-OHDPAT and mCPP in mice. Amitriptyline (10 mg/kg p.o., twice daily) significantly reduces serotonin transporter density by approximately 20% in cortex of mice.
Animal modelMice
Formulation & Dosage15, 30 mg/kg, i.p.; 10 mg/kg p.o.
References

Chem Biol. 2009 Jun 26;16(6):644-56.