(1R,2S)-VU0155041 是 VU0155041 的顺式区域异构体和 mGluR4 的部分激动剂。

(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.

(1R,2S)-VU0155041 is similar in potency with VU0155041 At both human and rat receptors (798 nM at human mGluR4 and 693 nM at rat mGluR4). (1R,2S)-VU0155041 (30 μM) induces concentration-dependent shifts in the baseline when examined in fold shift experiments using the thallium flux assay[1].

1263273-14-8

C14H15Cl2NO3

316.18

DMSO:54mg/mL (170.8mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years