U 89843A 是 γ-氨基丁酸 (GABA)A 受体的正变构调节剂。

U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.

In the alpha 1 beta 2 gamma 2 subtype of GABAA receptors expressed in human embryonic kidney cells, U 89843A dose-dependently enhanced 5 microM GABA-induced Cl- currents with a maximal enhancement of 362 +/- 91%, a half-maximal concentration of 2 +/- 0.4 microM and a slope factor of 1.1 +/- 0.4. U 89843A also inhibited [35S]t-butylbicyclophosphorothionate binding in rat cerebrocortical membranes with a similar half-maximal inhibitory concentration[1].

157013-32-6

C16H23N5

285.39

H2O:<8.05mg/mL
DMSO:<16.09mg/ml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years