Loreclezole 是一种选择性 GABAA 受体调节剂，可作为含有 β2 或 β3 亚基的受体的正变构调节剂，有抗癫痫作用。

Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.

Loreclezole, at concentrations above 6 microM, enhanced the degree and rate of apparent desensitization of the whole-cell current in a concentration-dependent manner [1]. The action of loreclezole depends on the type of beta subunit present in the receptor complex; receptors containing beta 2 or beta 3 subunits have >300-fold higher affinity for loreclezole than receptors containing a beta 1 subunit [2].

117857-45-1

C10H6Cl3N3

274.53

DMSO:90 mg/mL (327.83 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years