BMS927711 是一种有效的降钙素基因相关肽 (CGRP) 受体拮抗剂，其 Ki=0.027 nM，IC50=0.14 nM。

BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.

BMS-927711 is a full, competitive CGRP receptor antagonist with IC50 of 0.14±0.01 nM.

The ratios of the mean AUC (0-24 h) values for BMS-927711 (60, 100, and 300 mg/kg) in the DBS matrix, compare with plasma, are 0.5-0.6 across all doses in rats. Results from this study suggest a strong correlation of BMS-927711 concentrations between rat plasma and rat blood (DBS).BMS-927711 has good oral bioavailability in rat and cynomolgus monkey, attractive overall preclinical properties, and shows dose-dependent activity in a primate model of CGRP-induced facial blood flow

1289023-67-1

C28H28F2N6O3

534.568

BHV-3000;BMS927711;BMS 927711;BMS-927711

DMSO:10 mg/mL
Ethanol:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years