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Lamotrigine(BW430C LTG)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lamotrigine(BW430C LTG)图片
CAS NO:84057-84-1
规格:≥98%
包装与价格:
包装价格(元)
2g电议
5g电议
10g电议
25g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)256.09
FormulaC9H7Cl2N5
CAS No.84057-84-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 10 mg/mL (39.0 mM)
Water: <1 mg/mL
Ethanol: 3 mg/mL (11.7 mM)
Solubility (In vivo)0.5% methylcellulose: 30 mg/mL
SynonymsBW-430C; Lamotrigine, Lamictal, BW 430C; BW430C; Crisomet, Lamictin, Lamitor
实验参考方法
In Vitro

In vitro activity: Lamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected. Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels. Lamotrigine does not induce PCP-like central nervous system (CNS) effects, does not act by direct inhibition at the NMDA receptor, and would be expected to be devoid of the undesirable effects associated with NMDA blockade.

In VivoIn mice and rats, lamotrigine prevents MES- and pentetrazol-induced hindlimb extension, suggesting an antiepileptic profile in animals. These effects peak 1 hour after lamotrigine administration and persist for more than 24 hours. Lamotrigine is active in the electrically evoked EEG after-discharge test, which is thought to indicate activity against both simple and complex partial seizures. After-discharge duration is reduced dose-dependently by lamotrigine in rats at intravenous doses>5 mg/kg.
Animal modelDog/Rat
Formulation & DosageDissolved in 0.25% methylcellulose solution; 4.5 (dogs) and 11.7 (rats) mg /kg; i.v. injection
References

Drugs. 1993 Jul;46(1):152-76; Epilepsia. 1986 Sep-Oct;27(5):483-9.