PFI-90 是组蛋白去甲基化酶 (KDM3B) 的选择性抑制剂，可抑制 PAX3-FOXO1 的作用。它具有抗肿瘤活性的潜力，可诱导细胞凋亡和成肌分化，导致细胞死亡增加。详细信息来自专利 WO2021101929A1。

PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased.

PFI-90 (3 μΜ; 24 hours) increases apoptosis in RH4 and SCMC cells[1].

53995-62-3

C11H10N4O

214.228

Ethanol:20mg/mL (93.36 mM),Need ultrasonic and warming
DMSO:40mg/mL (186.72. mM)
H2O:insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years