Nanaomycin A 是一种醌类抗生素，可重新激活人类癌细胞中沉默的肿瘤抑制基因。 Nanaomycin A 是 DNMT3B 的特异性抑制剂 (IC50 = 500 nM)。

Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).

Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[1]. Nanaomycin A (10, 100, 1000, 10000 nM) had a distinct cytotoxic effect in HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines. Nanaomycin A (5 μM) had an 18-fold relative induction. Nanaomycin A (0.5, 5 μM) revealed induction of RASSF1A protein expression in A549 cells[2].

52934-83-5

C16H14O6

302.28

DMSO:95 mg/mL (314.28 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years