TC-A 2317 hydrochloride 是 AuRORa 激酶 A 的抑制剂，Ki 为 1.2 nM，而 AuRORa 激酶 B 的 Ki 为 101 nM。 TC-A 2317 hydrochloride 显示出抗肿瘤活性。

TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.

In rats, TC-A 2317 hydrochloride (30 mg/kg;p.o.) shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h). In the antitumor mice model, TC-A 2317 hydrochloride is effective without a decrease of body weight[1].

1245907-03-2

C19H29ClN6O

392.93

DMSO:<39.29mg/mL
Ethanol:<19.65mg/ml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years