Naphthol AS-E 是一种具有细胞渗透性的KIX-KID相互作用的抑制剂，可用于癌症研究。它直接结合 CBP 的 KIX 域，Kd为 8.6 μM，阻断 KIX 域和 KID 域的相互作用，IC50为 2.26 μM。

nAS-E is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.

nAS-E could reverse bone loss induced by MDA-MB-231 tumour.?These results suggest that small molecules targeting CREB-CBP interaction to inhibit CREB-mediated gene transcription might be a potential approach for the treatment of breast cancer bone metastasis[1].

92-78-4

C17H12ClNO2

297.74

色酚 AS-E;nAS-E

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years