| CAS NO: | 607742-69-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 353.44 |
|---|---|
| Formula | C19H19N3O2S |
| CAS No. | 607742-69-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 78 mg/mL (220.7 mM) |
| Water: <1 mg/mL | |
| Ethanol: 2 mg/mL (5.7 mM) | |
| Solubility (In vivo) | 2% DMSO, 48% PEG300, 2% Tween 80 and 48% water: 5mg/mL |
| Synonyms | GSK 742457; GSK-742457; RVT-101; SB742457; SB 742457; GSK742457; SB-742457; RVT 101; RVT101 |
| In Vitro | In vitro activity: SB-742457 is a selective 5-HT6 receptor antagonist with cognition, memory, and learning-enhancing effects. SB-742457 is a novel cognitive enhancing agent for Alzheimer's disease. SB-742457 is a potential agent added to stablize donepezil treatment in subjects with mild-to-moderate Alzheimer's disease. |
|---|---|
| In Vivo | SB-742457 is a potent and selective 5-HT6 receptor antagonist that is shown to reverse a scopolamine induced learning deficit in the novel object recognition test and to enhance performance in a water maze task by aged rats. |
| Animal model | N/A |
| Formulation & Dosage | N/A |
| References | Neurotherapeutics. 2008 Jul;5(3):458-69. |
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