OSMI-1 是O-GlcNAc 转移酶的选择性抑制剂，IC50值为 2.7 μM。它抑制哺乳动物细胞系中的蛋白 O-连接的 N-乙酰氨基葡萄糖，而没有定性地改变细胞表面 N-或 O-连接的聚糖。

OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor (IC50: 2.7 μM).

OSMI-1 inhibits OGT activity in cells. OSMI-1 (50 μM; 24 hours; CHO cells) treatment reduces the viability by about 50% after 24 hours. OSMI-1 (10-100 μM; 24 hours; CHO cells) treatment decreases global O-linked N-acetylglucosamine (O-GlcNAcylation) a dose-dependent manner [1].

The zebrafish model is used to investigate OSM1-1 acute toxicity in vivo. The LC50 of OSM1-1 is 0.031?mg/mL (56?μM, 12?h) and 0.025?mg/mL (45?μM, 24?h) in zebrafish model[2].

1681056-61-0

C28H25N3O6S2

563.65

DMSO:83.33 mg/mL (147.84 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years