IbigluSTAT (L-Malic acid) 是一种选择性的、脑渗透性的和别构的葡萄糖神经酰胺合酶抑制剂。 IbigluSTAT (L-Malic acid) 可用于关于 PD 帕金森病、法布里和戈谢氏 SRT 的研究。

Ibiglustat (L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase. Ibiglustat (L-Malic acid) can be used in studies about PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s.

Ibiglustat (L-Malic acid) (1 μM) treated Fabry disease cells are close to the physiological level in untreated WT cells in GL-3 levels. Ibiglustat (L-Malic acid) prevents additional GL-3 accumulation and ameliorates the abundant GL-3 levels in FD cardiomyocytes[4].

1629063-78-0

C24H30FN3O7S

523.57

Venglustat (L-Malic acid);Ibiglustat L-Malic acid;SAR402671 (L-Malic acid)

DMSO:90 mg/mL (171.9 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years