OT-82 is a potent, selective and orally active NAMPT inhibitor.

OT-82 was also more toxic towards patients-derived leukemic cells versus healthy bone marrow-derived hematopoietic precursors.?OT-82 was shown to induce cell death by inhibiting nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the salvage pathway of NAD synthesis.

In mice, optimization of OT-82 dosing and dietary niacin further expanded the compound's therapeutic index.?In toxicological studies conducted in mice and nonhuman primates, OT-82 showed no cardiac, neurological or retinal toxicities observed with other NAMPT inhibitors and had no effect on mouse aging or longevity.?Hematopoietic and lymphoid organs were identified as the primary targets for dose limiting toxicity of OT-82 in both species.

1800487-55-1

C26H21FN4O

424.47

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years