Methotrexate metabolite 是甲氨蝶呤的活性代谢物，可抑制寄生虫生长。

Methotrexate metabolite is the active metabolite of Methotrexate which is a folic acid antagonist. Methotrexate metabolite inhibits parasite growth.

Methotrexate metabolite was the most active, with 50% inhibitory concentrations in vitro of 446 ng/ml against the antifolate-sensitive strain and 812 ng/ml against the highly resistant strain under physiological folate conditions. Methotrexate metabolite potentiates the activity of the sulfone dapsone, an inhibitor of dihydropteroate synthase, but not that of chlorcycloguanil, a known inhibitor of dihydrofolate reductase (DHFR)[2].

19741-14-1

C15H15N7O2

325.33

甲喋呤杂质E;DAMPA

DMSO:4 mg/mL (12.30 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years