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Methyltetrazine-PEG12-DBCO
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Methyltetrazine-PEG12-DBCO图片
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
Methyltetrazine-PEG12-DBCO是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
Canonical SMILESCC1=NN=C(C2=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCC(N3C4=CC=CC=C4C#CC5=CC=CC=C5C3)=O)=O)C=C2)N=N1
分子式C52H70N6O14
分子量1003.14
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Methyltetrazine-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562