Gedunin 是从印楝种子中提取的一种重要柠檬苦素，具有抗癌、抗病毒、抗炎和杀虫活性。它可阻断 SARS-CoV-2 病毒进入人宿主细胞，用于 COVID-19 研究。它是HSP90抑制剂，诱导 HSP90 依赖的蛋白降解，抑制卵巢癌细胞增殖。

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.

Gedunin treatment is highly effective in inducing death of pancreatic cancer cells via intrinsic and extrinsic mediated apoptosis.?Gedunin inhibited metastasis of pancreatic cancer cells by decreasing their EMT, invasive, migratory and colony formation capabilities.?Gedunin treatment also inhibited sonic hedgehog signaling pathways.?Further, experiments with recombinant sonic hedgehog protein and Gli inhibitor (Gant-61) demonstrated that gedunin induces its anti-metastatic effect through inhibition of sonic hedgehog signaling.?The anti-cancer effect of gedunin was further validated using xenograft mouse model.

2753-30-2

C28H34O7

482.573

DMSO:60 mg/ml (124.33 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years