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CMS-121
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CMS-121图片
CAS NO:1353224-53-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
CMS121
产品介绍
CMS-121 是喹诺酮衍生物,对乙酰辅酶 A 羧化酶 1 具有抑制作用,具有口服活性。CMS-121具有保护 HT22 细胞免受缺血和氧化损伤的活性,EC50分别为7 nM和200 nM。CMS-121具有强大的抗炎,抗氧化,神经保护和肾保护作用。

产品描述

CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.

体外活性

CMS-121 can increase acetyl-CoA in cells. CMS-121 (1 μM; 4 hours; HT22 cells) treatment also increases the phosphorylation of ACC1 at serine 79.[1].

体内活性

CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. CMS-121 (~20 mg/kg; p.o; daily; for 4 months; female SAMP8 mice) treatment decreases cognitive decline and metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. [1].

Cas No.

1353224-53-9

分子式

C20H19NO3

分子量

321.37

别名

CMS121

储存和溶解度

DMSO:50mg/mL (155.58mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years