GNF-PF-3777 是人吲哚胺2，3-双加氧酶 2 (hIDO2) 抑制剂，能够降低IDO2活性，Ki=为 0.97 μM。

GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).

GNF-PF-3777 (Compound 5i) is a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity (EC50: 0.82 μM) [2]. GNF-PF-3777 has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogs lack LORA activity [3].

77603-42-0

C15H7N3O4

293.23

8-Nitrotryptanthrin

DMSO:6.4 mg/mL (21.83 mM),Need warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years