| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 别名 | FC-1271a D4 |
| Canonical SMILES | ClCC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(C=C3)OC([2H])([2H])C([2H])([2H])O |
| 分子式 | C24H19ClD4O2 |
| 分子量 | 382.9 |
| 溶解度 | Acetonitrile: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ospemifene-d4is intended for use as an internal standard for the quantification of ospemifene by GC- or LC-MS. Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM).1It binds to estrogen receptor α (ERα) and ERβ (Kis = 380 and 410 nM, respectively). It increases vaginal weight and vaginal epithelial height (ED50s = 0.48 and 0.39 mg/kg per day, respectively) in an ovariectomized rat model of menopause. Ospemifene also increases progesterone receptor protein expression in vaginal epithelium and stroma and inhibits estrogen response element-mediated transactivation induced by 17β-estradiol in a reporter assay using MCF-7 cells. Formulations containing ospemifene have been used in the treatment of vulvar and vaginal atrophy-induced dyspareunia. 1.Unkila, M., Kari, S., Yatkin, E., et al.Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopauseJ. Steroid Biochem. Mol. Biol.138107-115(2013) |
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