| CAS NO: | 1329809-23-5 |
| 包装: | 1mg |
| 市场价: | 5216元 |
| Cas No. | 1329809-23-5 |
| 别名 | 决奈达隆 D6 |
| Canonical SMILES | CCCCC1=C(C(C2=CC=C(OC([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCCC)CCCC)C=C2)=O)C3=CC(NS(C)(=O)=O)=CC=C3O1.Cl |
| 分子式 | C31H38D6N2O5S.HCl |
| 分子量 | 599.3 |
| 溶解度 | Chloroform: Slightly soluble,Methanol: Slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dronedarone-d6is intended for use as an internal standard for the quantification of dronedarone by GC- or LC-MS. Dronedarone is an antiarrhythmic agent and a derivative of amiodarone .1,2It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively).2Dronedarone (50 and 100 mg/kg) reduces sinus frequency and prolongs action potential duration (APD) in isolated rabbit ventricular myocardium. It increases atrial APD and the atrial effective refractory period (AERP) in a dog model of atrial fibrillation induced by rapid right atrial pacing.3Formulations containing dronedarone have been used in the treatment of atrial fibrillation. 1.Sun, W., Sarma, J.S., and Singh, B.N.Electrophysiological effects of dronedarone (SR33589), a noniodinated benzofuran derivative, in the rabbit heart: Comparison with amiodaroneCirculation100(22)2276-2281(1999) 2.Guillemare, E., Marion, A., Nisato, D., et al.Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cellsJ. Cardiovasc. Pharmacol.36(6)802-805(2000) 3.Saengklub, N., Limprasutr, V., Sawangkoon, S., et al.Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillationExp. Anim.66(3)251-258(2017) |
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