Sodium dichloroacetate 是癌细胞线粒体中的一种代谢调节剂，具有抗癌活性。它抑制丙酮酸脱氢酶激酶，从而导致肿瘤微环境中的乳酸减少。它增加活性氧的产生并促进癌细胞凋亡，还可作为NKCC抑制剂。

Dichloroacetate, a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.

2156-56-1

C2HCl2NaO2

150.92

bichloroacetic acid;Sodium Dichloroacetate;BCA;DCA;二氯乙酸钠;Sodium dichloroacetate (DCA);二氯醋酸酯

DMSO:15.1 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years