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Zuclomiphene D4 citrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Zuclomiphene D4 citrate图片
包装:1mg
市场价:1980元

产品介绍
ZuclomipheneD4citrate是Zuclomiphenecitrate的氘代物。Zuclomiphenecitrate具有抗雌激素的作用,比反式异构体更能抑制黄体生成激素(LH)的分泌。Zuclomiphenecitrate也是一种口服活性降胆固醇剂。
Canonical SMILESCl/C(C1=CC=CC=C1)=C(C2=CC=C(OC([2H])([2H])C([2H])([2H])N(CC)CC)C=C2)/C3=CC=CC=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O
分子式C32H32D4ClNO8
分子量602.11
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Zuclomiphene D4 citrate is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4].

[1]. Fontenot GK, et al. Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice. BJU Int. 2016 Feb;117(2):344-50. [2]. Mikkelson TJ, et al. Single-dose pharmacokinetics of clomiphene citrate in normal volunteers. Fertil Steril. 1986 Sep;46(3):392-6. [3]. Sutherland RL. Estrogen antagonists in chick oviduct: antagonist activity of eight synthetic triphenylethylene derivatives and their interactions with cytoplasmic and nuclear estrogen receptors. Endocrinology. 1981 Dec;109(6):2061-8. [4]. Ramsey RB, et al. The biochemical and morphological response of hydrolytic enzymes in the developing brain to hypocholesterolemic agents. Acta Neuropathol. 1980;49(2):89-94.