PhosphoramIDOn Disodium Salt 是一种金属蛋白酶 (metalloProtease) 抑制剂 。PhosphoramIDOn Disodium Salt抑制内皮素转化酶 (ECE) ，中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ，0.034 和 78 μM。

Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.

Phosphoramidon is a powerful inhibitor of thermolysin without inhibiting the other endopeptidases such as trypsin, papain, chymotrypsin. [1] Phosphoramidon reduces tumor cell invasion in CC531 cells. [2]

In rats bearing colon carcinoma CC531 xenografts, Phosphoramidon (250 mg/Rat i.p.) significantly reduces tumor cell growth. [2] Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice, and thus can be use to model Alzheimer's disease (AD). [3]

164204-38-0

C23H32N3Na2O10P

587.473

磷酰胺二钠;Phosphoramidon Disodium Salt

DMSO:169.9 mM
H2O:169.9 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years