您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Heparin sodium salt
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Heparin sodium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:9041-08-1
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品名称
肝素钠
Sodium heparinate
Heparin sodium
产品介绍
Heparin sodium salt 是一种抗凝剂,可与抗凝血酶III可逆地结合,使凝血酶因子IIa和Xa的失活速度加快,显着抑制外泌体-细胞相互作用。

产品描述

Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse proteins for numerous important biological activities.Heparin sodium salt significantly inhibits exosome-cell interactions.

体外活性

Heparin contains a speci?c pentasaccharide sequence that binds and activates the plasma proteinase inhibitor AT, which accounts for most of the increase in inhibitory activity toward Factor Xa induced by heparin. Heparin binds, via the speci?c pentasaccharide sequence, to AT is a two-step process, involving formation of an initial complex with a Kd of ~4×10?5M, followed by conformational changes in both the AT and saccharide moieties. Heparin 12-mer binds to FGF2 monomer covalently is able to induce FGFR activation (stimulate mitogenesis). [1] Heparin induces aggregation of platelets in citrated platelet-rich plasma and enhances platelet aggregation and serotonin secretion induced by other agents, and this action of heparin is blocked by substances that elevate platelet cyclic AMP and by EDTA but not by inhibitors of platelet cyclooxygenase. [2] Heparin controls, through a post-translational mechanism, the levels of specific cassettes of positively charged proteases inside mast cells. [3] Heparin activates the inhibition of thrombin by antithrombin by bringing them into close apposition, but there is also a direct activation of inhibition due to an overall conformational change induced by the binding to the core pentasaccharide present in both heparin and heparans. [4]

激酶实验

In vitro assay of CYP17: The in vitro CYP17 inhibitory activity of Galeterone is evaluated using rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing E. coli as the enzyme source. It involves the use of [21-3H]-17α-hydroxypregnenolone as the substrate, and CYP17 activity is measured by the amount of tritiated acetic acid formed during the cleavage of the C-21 side chain of the substrate. IC50 value is obtained directly from plots relating percentage inhibition versus inhibitor concentration over appropriate ranges.

Cas No.

9041-08-1

分子式

C26H42N2NaO37S5

分子量

1157.89

别名

肝素钠;Sodium heparinate;Heparin sodium

储存和溶解度

H2O:20 mg/mL,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years