NNK 是尼古丁亚硝化衍生物。它可以激活ERK1/2和PKCα，并在 Ser70 激活BCL2磷酸化，以及在Thr58和 Ser62激活c-Myc。它可用于构建肺癌小鼠模型，以及诱导人肺癌细胞的增殖和存活。

NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.

64091-91-4

C10H13N3O2

207.23

Nicotine-derived nitrosamine ketone

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years