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Dde Biotin-PEG4-alkyne
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Dde Biotin-PEG4-alkyne图片
CAS NO:1802908-00-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Dde Biotin-PEG4-alkyne 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。
Cas No.1802908-00-4
别名DDE-生物素-PEG4-炔
Canonical SMILESO=C(NCCOCCOCCOCCOCC/C(NCC#C)=C1C(CC(C)(C)CC\1=O)=O)CCCC[C@H]2SC[C@@]([C@@]2([H])N3)([H])NC3=O
分子式C32H50N4O8S
分子量650.83
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dde Biotin-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562