CUDA 是一种可溶性环氧水解酶抑制剂，对小鼠 sEH 和人 sEH 作用的IC50分别为 11.1 和 112 nM。它能选择性地上调过氧化物酶体增殖激活受体PPARα的活性，有用于心血管疾病的研究潜力。

CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases.

CUDA (10 μM; 18 hours) produced a 6-fold and 3-fold increase of PPARalpha in COS-7 cells. CUDA does not change the expression of PPARalpha protein. It competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, indicating that it acts as a PPARalpha ligand.

479413-68-8

C19H36N2O3

340.5

DMSO:25 mg/mL (73.42 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years